Item Type | Name |
Concept
|
Adenoviridae
|
Concept
|
Ammonium Chloride
|
Concept
|
Adenoviruses, Human
|
Concept
|
Antibiotics, Antineoplastic
|
Concept
|
Adenylyl Cyclases
|
Concept
|
Acetylglucosaminidase
|
Concept
|
Acrylamides
|
Concept
|
Calcimycin
|
Concept
|
Cyclic AMP
|
Concept
|
Blood Platelets
|
Concept
|
Amino Acid Sequence
|
Concept
|
Adenosine Triphosphate
|
Concept
|
Breast
|
Concept
|
Antigens, Polyomavirus Transforming
|
Concept
|
Antineoplastic Agents
|
Concept
|
Carcinoma, Squamous Cell
|
Concept
|
Cell Fractionation
|
Concept
|
Cell Line, Transformed
|
Concept
|
Cerebral Cortex
|
Concept
|
Androstadienes
|
Concept
|
Animals, Newborn
|
Concept
|
Carcinoma
|
Concept
|
Chromosome Banding
|
Concept
|
Antibodies, Monoclonal
|
Concept
|
Chromosomes, Human, Pair 8
|
Concept
|
Antigens, Viral, Tumor
|
Concept
|
Base Sequence
|
Concept
|
Carmustine
|
Concept
|
Cell Count
|
Concept
|
Cell Nucleus
|
Concept
|
Benzopyrans
|
Concept
|
Biotin
|
Concept
|
Carcinoma, Renal Cell
|
Concept
|
beta-Galactosidase
|
Concept
|
Butadienes
|
Concept
|
Endoribonucleases
|
Concept
|
Cattle
|
Concept
|
Cell Membrane
|
Concept
|
Cell Division
|
Concept
|
Chromatography, Gel
|
Concept
|
Clone Cells
|
Concept
|
Cell-Free System
|
Concept
|
Cesium
|
Concept
|
Flavonoids
|
Concept
|
Citric Acid Cycle
|
Concept
|
Cnidarian Venoms
|
Concept
|
Codon
|
Concept
|
Glutathione Transferase
|
Concept
|
Contact Lenses
|
Concept
|
Cricetulus
|
Concept
|
Cytosol
|
Concept
|
Hexosaminidases
|
Concept
|
Histamine
|
Concept
|
Culture Media
|
Concept
|
Cysteine
|
Concept
|
Dactinomycin
|
Concept
|
Cornea
|
Concept
|
Cycloheximide
|
Concept
|
Cysteine Endopeptidases
|
Concept
|
Cytoplasm
|
Concept
|
Dexamethasone
|
Concept
|
Electrolytes
|
Concept
|
Diet
|
Concept
|
Injections, Intraperitoneal
|
Concept
|
Insulin
|
Concept
|
Insulysin
|
Concept
|
Intermediate Filaments
|
Concept
|
Cytoskeleton
|
Concept
|
DNA Repair
|
Concept
|
Drosophila
|
Concept
|
Cathepsins
|
Concept
|
Cell Fusion
|
Concept
|
Genes, Regulator
|
Concept
|
Electrophysiology
|
Concept
|
Estradiol
|
Concept
|
Chromosomes, Human, Pair 10
|
Concept
|
Chromosomes, Human, Pair 9
|
Concept
|
Exons
|
Concept
|
Extracellular Space
|
Concept
|
Conjunctiva
|
Concept
|
Drosophila melanogaster
|
Concept
|
Interferons
|
Concept
|
Introns
|
Concept
|
Egtazic Acid
|
Concept
|
Microtubule-Associated Proteins
|
Concept
|
Spindle Apparatus
|
Concept
|
Genes, Dominant
|
Concept
|
Genes
|
Concept
|
Glial Fibrillary Acidic Protein
|
Concept
|
Fibroblast Growth Factors
|
Concept
|
Food Contamination
|
Concept
|
Oncogenes
|
Concept
|
Glucose Oxidase
|
Concept
|
Hippocampus
|
Concept
|
Embryo, Mammalian
|
Concept
|
DNA Replication
|
Concept
|
Hydrogen Peroxide
|
Concept
|
Liver Neoplasms
|
Concept
|
Insulin-Like Growth Factor I
|
Concept
|
Electroretinography
|
Concept
|
Enzyme Induction
|
Concept
|
Genetic Carrier Screening
|
Concept
|
Escherichia coli
|
Concept
|
Fluorescent Antibody Technique
|
Concept
|
Interleukin-1
|
Concept
|
Light
|
Concept
|
Carcinoma, Hepatocellular
|
Concept
|
Metalloendopeptidases
|
Concept
|
Microfilament Proteins
|
Concept
|
Microbodies
|
Concept
|
Mitosis
|
Concept
|
Platelet-Derived Growth Factor
|
Concept
|
Immunohistochemistry
|
Concept
|
Molecular Sequence Data
|
Concept
|
Pancreatic Neoplasms
|
Concept
|
Methylprednisolone
|
Concept
|
Molecular Biology
|
Concept
|
Cricetinae
|
Concept
|
HeLa Cells
|
Concept
|
Nerve Growth Factors
|
Concept
|
Peptide Hydrolases
|
Concept
|
Endopeptidases
|
Concept
|
Metaphase
|
Concept
|
Pigment Epithelium of Eye
|
Concept
|
Phosphoprotein Phosphatases
|
Concept
|
Muscle Proteins
|
Concept
|
Potassium
|
Concept
|
Prostatic Neoplasms
|
Concept
|
Hybrid Cells
|
Concept
|
Image Processing, Computer-Assisted
|
Concept
|
Receptor, Insulin
|
Concept
|
Repressor Proteins
|
Concept
|
Radiation Injuries, Experimental
|
Concept
|
Intermediate Filament Proteins
|
Concept
|
Spasms, Infantile
|
Concept
|
Cohort Studies
|
Concept
|
Rats, Inbred Lew
|
Concept
|
Cadherins
|
Concept
|
Interleukin-6
|
Concept
|
Sodium
|
Concept
|
Serotonin
|
Concept
|
Septal Nuclei
|
Concept
|
Thymidine
|
Concept
|
Transcription, Genetic
|
Concept
|
Protein Biosynthesis
|
Concept
|
Tretinoin
|
Concept
|
Proto-Oncogene Proteins pp60(c-src)
|
Concept
|
CHO Cells
|
Concept
|
Tumor Necrosis Factor-alpha
|
Concept
|
Sequence Homology, Amino Acid
|
Concept
|
Iodine Radioisotopes
|
Concept
|
Ultraviolet Rays
|
Concept
|
Lysosomes
|
Concept
|
Kinetochores
|
Concept
|
Transforming Growth Factors
|
Concept
|
Weight Loss
|
Concept
|
Cell Culture Techniques
|
Concept
|
Caspases
|
Concept
|
Guanine Nucleotide Exchange Factors
|
Concept
|
Tumor Cells, Cultured
|
Concept
|
S Phase
|
Concept
|
Transforming Growth Factor beta
|
Concept
|
NF-kappa B
|
Concept
|
HMGA2 Protein
|
Concept
|
Genes, Tumor Suppressor
|
Concept
|
Genes, Wilms Tumor
|
Concept
|
PC12 Cells
|
Concept
|
Antigens, CD
|
Concept
|
3T3 Cells
|
Concept
|
Microinjections
|
Concept
|
Microsomes
|
Concept
|
Mitochondria
|
Concept
|
DNA Probes
|
Concept
|
Culture Media, Conditioned
|
Concept
|
Paclitaxel
|
Concept
|
Proto-Oncogene Proteins c-fos
|
Concept
|
Gene Expression
|
Concept
|
Cyclic AMP Response Element-Binding Protein
|
Concept
|
T-Lymphocyte Subsets
|
Concept
|
RNA Interference
|
Concept
|
Menopause
|
Concept
|
Genes, Immediate-Early
|
Concept
|
Genes, Reporter
|
Concept
|
Paraffin Embedding
|
Concept
|
Nerve Crush
|
Concept
|
Optic Nerve Diseases
|
Concept
|
Neurites
|
Concept
|
MAP Kinase Kinase 1
|
Concept
|
MAP Kinase Kinase 2
|
Concept
|
Crystallography, X-Ray
|
Concept
|
DNA, Complementary
|
Concept
|
Cell Proliferation
|
Concept
|
Chemokines
|
Concept
|
Disease Progression
|
Concept
|
Thapsigargin
|
Concept
|
ras Proteins
|
Concept
|
E2F Transcription Factors
|
Concept
|
ets-Domain Protein Elk-1
|
Concept
|
Basic-Leucine Zipper Transcription Factors
|
Concept
|
Centrosome
|
Concept
|
Antineoplastic Agents, Alkylating
|
Concept
|
Brain-Derived Neurotrophic Factor
|
Concept
|
Fas Ligand Protein
|
Concept
|
ras Guanine Nucleotide Exchange Factors
|
Concept
|
Chemokine CCL5
|
Concept
|
Protein Tyrosine Phosphatases
|
Concept
|
Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
|
Concept
|
GTP Phosphohydrolases
|
Concept
|
In Situ Hybridization, Fluorescence
|
Concept
|
Primary Cell Culture
|
Concept
|
NIH 3T3 Cells
|
Concept
|
Proto-Oncogene Proteins c-ets
|
Concept
|
Cyclin-Dependent Kinase 4
|
Concept
|
Proteasome Endopeptidase Complex
|
Concept
|
Mitogen-Activated Protein Kinase 3
|
Concept
|
Mitogen-Activated Protein Kinase 7
|
Concept
|
COS Cells
|
Concept
|
Codon, Initiator
|
Concept
|
Proto-Oncogene Proteins c-raf
|
Concept
|
Proto-Oncogene Proteins B-raf
|
Concept
|
Cell Growth Processes
|
Concept
|
Caspase 1
|
Concept
|
rac GTP-Binding Proteins
|
Concept
|
Amino Acid Motifs
|
Concept
|
rap1 GTP-Binding Proteins
|
Concept
|
Mitogen-Activated Protein Kinase Kinases
|
Concept
|
Loss of Heterozygosity
|
Concept
|
Catalytic Domain
|
Concept
|
I-kappa B Proteins
|
Concept
|
BRCA2 Protein
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
Concept
|
Phorbols
|
Concept
|
Phorbol Esters
|
Concept
|
Plant Extracts
|
Concept
|
Precipitin Tests
|
Concept
|
Promoter Regions, Genetic
|
Concept
|
Early Growth Response Protein 1
|
Concept
|
Ribonucleases
|
Concept
|
Syndecan-2
|
Concept
|
DNA Fragmentation
|
Concept
|
Protein Phosphatase 1
|
Concept
|
Shc Signaling Adaptor Proteins
|
Concept
|
HEK293 Cells
|
Concept
|
Cytokine Receptor gp130
|
Concept
|
Tumor Necrosis Factors
|
Concept
|
Trypsin
|
Concept
|
Subcellular Fractions
|
Concept
|
Vero Cells
|
Concept
|
Adaptor Proteins, Signal Transducing
|
Concept
|
Temperature
|
Concept
|
Zinc
|
Concept
|
Blotting, Western
|
Concept
|
Inhibitor of Differentiation Protein 1
|
Concept
|
Transforming Growth Factor alpha
|
Concept
|
Cyclins
|
Concept
|
Tetradecanoylphorbol Acetate
|
Concept
|
Culture Media, Serum-Free
|
Concept
|
Transcription Factor RelA
|
Concept
|
Benzophenanthridines
|
Concept
|
Tubulin
|
Concept
|
Phorbol 12,13-Dibutyrate
|
Concept
|
Ionomycin
|
Concept
|
Survival Rate
|
Concept
|
Amyloid beta-Peptides
|
Concept
|
Cyclin-Dependent Kinases
|
Concept
|
CD3 Complex
|
Concept
|
GTP-Binding Proteins
|
Concept
|
Dimerization
|
Concept
|
Cyclin E
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
Concept
|
Xenograft Model Antitumor Assays
|
Concept
|
Homeodomain Proteins
|
Concept
|
Serum Response Factor
|
Concept
|
Cyclin A
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
Concept
|
raf Kinases
|
Concept
|
History, 20th Century
|
Concept
|
Transcriptome
|
Concept
|
CASP8 and FADD-Like Apoptosis Regulating Protein
|
Concept
|
Insulin Receptor Substrate Proteins
|
Concept
|
Ribosomal Protein S6 Kinases, 70-kDa
|
Concept
|
Vascular Endothelial Growth Factor A
|
Concept
|
Cell Line, Tumor
|
Concept
|
14-3-3 Proteins
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p27
|
Concept
|
Methyl-CpG-Binding Protein 2
|
Concept
|
Genes, Neoplasm
|
Concept
|
Protein Phosphatase 2
|
Concept
|
Gene Knock-In Techniques
|
Concept
|
Islet Amyloid Polypeptide
|
Concept
|
Synthetic Biology
|
Concept
|
Alzheimer Disease
|
Concept
|
Brain Neoplasms
|
Concept
|
Calcium
|
Concept
|
Cell Line
|
Concept
|
Cells, Cultured
|
Concept
|
Chromatin
|
Concept
|
Chromosomes, Human, Pair 16
|
Concept
|
Disease Models, Animal
|
Concept
|
Ecdysone
|
Concept
|
Electron Transport
|
Concept
|
Epidermal Growth Factor
|
Concept
|
India
|
Concept
|
Lymphocyte Activation
|
Concept
|
Membrane Potentials
|
Concept
|
Proto-Oncogenes
|
Concept
|
Staining and Labeling
|
Concept
|
Simian virus 40
|
Concept
|
T-Lymphocytes
|
Concept
|
Vimentin
|
Concept
|
X Chromosome
|
Concept
|
Tumor Suppressor Protein p53
|
Concept
|
Fibroblast Growth Factor 2
|
Concept
|
Cyclic AMP-Dependent Protein Kinases
|
Concept
|
DNA Primers
|
Concept
|
Troponin C
|
Concept
|
Okadaic Acid
|
Concept
|
Cyclin D1
|
Concept
|
Genetic Predisposition to Disease
|
Concept
|
Oncogene Proteins v-raf
|
Concept
|
Telomere-Binding Proteins
|
Concept
|
Mammary Glands, Human
|
Concept
|
MAP Kinase Kinase 5
|
Concept
|
Cyclin-Dependent Kinase 2
|
Concept
|
G-Protein-Coupled Receptor Kinase 2
|
Concept
|
Cystatin M
|
Academic Article
|
Mutations in a zinc-binding domain of human insulin-degrading enzyme eliminate catalytic activity but not insulin binding.
|
Academic Article
|
Cloning and characterization of MST4, a novel Ste20-like kinase.
|
Academic Article
|
Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.
|
Academic Article
|
A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity.
|
Academic Article
|
ERK7 is an autoactivated member of the MAPK family.
|
Academic Article
|
ERK8, a new member of the mitogen-activated protein kinase family.
|
Academic Article
|
ERK7 expression and kinase activity is regulated by the ubiquitin-proteosome pathway.
|
Academic Article
|
Human bronchial smooth muscle cell lines show a hypertrophic phenotype typical of severe asthma.
|
Academic Article
|
Anthrax edema toxin inhibits endothelial cell chemotaxis via Epac and Rap1.
|
Academic Article
|
The C-terminal domain of human insulin degrading enzyme is required for dimerization and substrate recognition.
|
Academic Article
|
Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
|
Academic Article
|
NMR assignment of rat Raf kinase inhibitor protein.
|
Academic Article
|
A feed-forward loop involving protein kinase Calpha and microRNAs regulates tumor cell cycle.
|
Academic Article
|
Raf kinase inhibitory protein function is regulated via a flexible pocket and novel phosphorylation-dependent mechanism.
|
Academic Article
|
tRNA over-expression in breast cancer and functional consequences.
|
Academic Article
|
Innate immune and chemically triggered oxidative stress modifies translational fidelity.
|
Academic Article
|
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
|
Academic Article
|
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
|
Academic Article
|
Characterization of the Raf kinase inhibitory protein (RKIP) binding pocket: NMR-based screening identifies small-molecule ligands.
|
Academic Article
|
Sodium as a mediator of non-phorbol tumor promoter action. Down-modulation of the epidermal growth factor receptor by palytoxin.
|
Academic Article
|
Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target.
|
Academic Article
|
Identification of novel metastasis suppressor signaling pathways for breast cancer.
|
Academic Article
|
Anthrax edema factor potency depends on mode of cell entry.
|
Academic Article
|
Inducible expression and cellular localization of insulin-degrading enzyme in a stably transfected cell line.
|
Academic Article
|
Structure-activity studies of the nonphorbol tumor promoter palytoxin in Swiss 3T3 cells.
|
Academic Article
|
Cloning and expression of the cDNA for a Drosophila insulin-degrading enzyme.
|
Academic Article
|
Efficacy of the multi-kinase inhibitor enzastaurin is dependent on cellular signaling context.
|
Academic Article
|
Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer.
|
Academic Article
|
RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes.
|
Academic Article
|
Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells.
|
Academic Article
|
Functional analysis of conserved residues in the active site of insulin-degrading enzyme.
|
Academic Article
|
Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.
|
Academic Article
|
Anti-tumor effects of an engineered "killer" transfer RNA.
|
Academic Article
|
Apoptosis induced by differentiation or serum deprivation in an immortalized central nervous system neuronal cell line.
|
Academic Article
|
The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis.
|
Academic Article
|
Effect of complementary pathway blockade on efficacy of combination enzastaurin and rapamycin.
|
Academic Article
|
A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer.
|
Academic Article
|
Role of MAP kinase activation in bovine tracheal smooth muscle mitogenesis.
|
Academic Article
|
Identification of zinc ligands of the insulin-degrading enzyme.
|
Academic Article
|
Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factor.
|
Academic Article
|
An evolutionarily conserved TGF-alpha/insulin-degrading enzyme.
|
Academic Article
|
Palytoxin down-modulates the epidermal growth factor receptor through a sodium-dependent pathway.
|
Academic Article
|
Therapeutic parameters of methylprednisolone treatment for retinal photic injury in a rat model.
|
Academic Article
|
Drosophila insulin degrading enzyme and rat skeletal muscle insulin protease cleave insulin at similar sites.
|
Academic Article
|
An insulin epidermal growth factor-binding protein from Drosophila has insulin-degrading activity.
|
Academic Article
|
Regulation of the epidermal growth factor receptor by growth-modulating agents.
|
Academic Article
|
Phosphorylation at threonine-654 is not required for negative regulation of the epidermal growth factor receptor by non-phorbol tumor promoters.
|
Academic Article
|
Regulation of epidermal growth factor receptor gene expression by retinoic acid and epidermal growth factor.
|
Academic Article
|
Basic and acidic fibroblast growth factors modulate the epidermal growth factor receptor by a protein kinase C-independent pathway.
|
Academic Article
|
Identification of a novel receptor in Drosophila for both epidermal growth factor and insulin.
|
Academic Article
|
Transforming growth factor-beta increases transcription of the genes encoding the epidermal growth factor receptor and fibronectin in normal rat kidney fibroblasts.
|
Academic Article
|
Characterization of rodent epidermal growth factor receptor transcripts using a mouse genomic probe.
|
Academic Article
|
Decreased levels of hepatic epidermal growth factor receptors in obese hyperglycemic rodents.
|
Academic Article
|
Heterologous regulation of the epidermal growth factor receptor by palytoxin, a non-12-O-tetradecanoylphorbol-13-acetate-type tumor promoter.
|
Academic Article
|
Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster.
|
Academic Article
|
Epidermal growth factor (EGF) receptor T669 peptide kinase from 3T3-L1 cells is an EGF-stimulated "MAP" kinase.
|
Academic Article
|
Temporal parameters of low energy laser irradiation for optimal delay of post-traumatic degeneration of rat optic nerve.
|
Academic Article
|
Substance abuse in pregnant women: recent experience at the Perinatal Center for Chemical Dependence of Northwestern Memorial Hospital.
|
Academic Article
|
Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.
|
Academic Article
|
Basic fibroblast-like growth factor is present in the conditioned medium of simian sarcoma virus transformed NRK cells.
|
Academic Article
|
Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.
|
Academic Article
|
Selective cleavage by endo-beta-N-acetylglucosaminidase H at individual glycosylation sites of Sindbis virion envelope glycoproteins.
|
Academic Article
|
Host-dependent variation of asparagine-linked oligosaccharides at individual glycosylation sites of Sindbis virus glycoproteins.
|
Academic Article
|
Mitogen-activated protein kinase regulates the epidermal growth factor receptor through activation of a tyrosine phosphatase.
|
Academic Article
|
Insulin-like growth factor I receptor signaling in differentiation of neuronal H19-7 cells.
|
Academic Article
|
Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation.
|
Academic Article
|
Functional human insulin-degrading enzyme can be expressed in bacteria.
|
Academic Article
|
Different protein kinase C isoforms determine growth factor specificity in neuronal cells.
|
Academic Article
|
Activation of Raf-1 signaling by protein kinase C through a mechanism involving Raf kinase inhibitory protein.
|
Academic Article
|
Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme.
|
Academic Article
|
Identification of an epidermal growth factor receptor transcriptional repressor.
|
Academic Article
|
Oxidative stress-mediated down-regulation of bcl-2 promoter in hippocampal neurons.
|
Academic Article
|
Role of threonine residues in regulation of the epidermal growth factor receptor by protein kinase C and mitogen-activated protein kinase.
|
Academic Article
|
Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.
|
Academic Article
|
Proteins interacting with the tuberous sclerosis gene products.
|
Academic Article
|
Mutation of Di-leucine residues in the juxtamembrane region alters EGF receptor expression.
|
Academic Article
|
Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line.
|
Academic Article
|
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
|
Academic Article
|
CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.
|
Academic Article
|
A proline- and glutamine-rich protein promotes apoptosis in neuronal cells.
|
Academic Article
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Differential effect of cycloheximide on neuronal and glioma cells treated with chemotherapy and radiation.
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Academic Article
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Immunohistochemical demonstration of the zinc metalloprotease insulin-degrading enzyme in normal and malignant human breast: correlation with tissue insulin levels.
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Cytoplasmic/nuclear localization of tuberin in different cell lines.
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Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations.
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Tuberous sclerosis gene products in proliferation control.
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Identification of the cleavage sites of transforming growth factor alpha by insulin-degrading enzymes.
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mTOR phosphorylated at S2448 binds to raptor and rictor.
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Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme.
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Evidence for cell cycle-dependent, rapamycin-resistant phosphorylation of ribosomal protein S6 at S240/244.
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FGF induces a switch in death receptor pathways in neuronal cells.
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Tuberous sclerosis causing mutants of the TSC2 gene product affect proliferation and p27 expression.
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Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells.
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Regulation of airway smooth muscle cyclin D1 transcription by protein kinase C-delta.
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Tuberin negatively affects BCL-2's cell survival function.
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Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR.
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Academic Article
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Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas.
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Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor.
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Academic Article
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Nuclear/cytoplasmic localization of Akt activity in the cell cycle.
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Academic Article
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Tuberin, p27 and mTOR in different cells.
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Academic Article
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The TSC1 gene product, hamartin, negatively regulates cell proliferation.
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Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation.
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Academic Article
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Ras mediates cell survival by regulating tuberin.
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MAP kinase meets mitosis: a role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation.
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Academic Article
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Modulation of the MAP kinase signaling cascade by Raf kinase inhibitory protein.
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Academic Article
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p70 S6K1 nuclear localization depends on its mTOR-mediated phosphorylation at T389, but not on its kinase activity towards S6.
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Academic Article
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Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
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Academic Article
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Proliferation potential of human amniotic fluid stem cells differently responds to mercury and lead exposure.
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Academic Article
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Nonheritable cellular variability accelerates the evolutionary processes of cancer.
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Academic Article
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14-3-3 proteins are involved in the regulation of mammalian cell proliferation.
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Academic Article
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NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta.
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Academic Article
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Akt regulates nuclear/cytoplasmic localization of tuberin.
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Academic Article
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HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
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Academic Article
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Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.
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Academic Article
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Expression of metalloprotease insulin-degrading enzyme insulysin in normal and malignant human tissues.
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Academic Article
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Immunohistochemical evidence of ubiquitous distribution of the metalloendoprotease insulin-degrading enzyme (IDE; insulysin) in human non-malignant tissues and tumor cell lines.
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Academic Article
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CDKs as therapeutic targets for the human genetic disease tuberous sclerosis?
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MicroRNA-regulated feed forward loop network.
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Academic Article
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Embryoid body formation of human amniotic fluid stem cells depends on mTOR.
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Academic Article
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MAP kinase regulation of the mitotic spindle checkpoint.
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Academic Article
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RKIP regulates MAP kinase signaling in cells with defective B-Raf activity.
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Academic Article
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Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells.
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Academic Article
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RKIP inhibition in cervical cancer is associated with higher tumor aggressive behavior and resistance to cisplatin therapy.
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Academic Article
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An evolutionarily conserved enzyme degrades transforming growth factor-alpha as well as insulin.
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Academic Article
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Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
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Academic Article
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Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.
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Academic Article
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Cyclin D1 is required for S phase traversal in bovine tracheal myocytes.
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Academic Article
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Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways.
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Academic Article
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Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.
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Academic Article
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Tuberin activates the proapoptotic molecule BAD.
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Academic Article
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Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236.
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Academic Article
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An integrated view of cyclin E function and regulation.
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Academic Article
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Conceptualizing cancer drugs as classifiers.
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Academic Article
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A prognostic gene signature for metastasis-free survival of triple negative breast cancer patients.
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Academic Article
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RKIP and HMGA2 regulate breast tumor survival and metastasis through lysyl oxidase and syndecan-2.
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Academic Article
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Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions.
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Academic Article
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Har Gobind Khorana 1922-2011.
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Academic Article
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RKIP structure drives its function: a three-state model for regulation of RKIP.
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Academic Article
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Retraction: Oct-3 is a maternal factor required for the first mouse embryonic division.
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Academic Article
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Raf kinase inhibitory protein (RKIP) as a metastasis suppressor: regulation of signaling networks in cancer.
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Academic Article
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Noise-Driven Phenotypic Heterogeneity with Finite Correlation Time in Clonal Populations.
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Academic Article
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Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages.
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Academic Article
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Interaction of tRNA with MEK2 in pancreatic cancer cells.
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Academic Article
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Gene expression in local stroma reflects breast tumor states and predicts patient outcome.
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Academic Article
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Insulin-Degrading Enzyme Does Not Require Peroxisomal Localization for Insulin Degradation.
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Raf kinase inhibitor protein: lessons of a better way for ß-adrenergic receptor activation in the heart.
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Academic Article
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Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome.
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Academic Article
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Targeting Raf Kinase Inhibitory Protein Regulation and Function.
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Academic Article
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Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism.
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Academic Article
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Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer
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Academic Article
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Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer.
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Academic Article
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Observation and Control of Gene Expression Noise: Barrier Crossing Analogies Between Drug Resistance and Metastasis.
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Academic Article
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Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response.
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Academic Article
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Limited inhibition of multiple nodes in a driver network blocks metastasis.
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Academic Article
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Tumor Extracellular Vesicles Regulate Macrophage-Driven Metastasis through CCL5.
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Academic Article
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New strategies for targeting kinase networks in cancer.
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Academic Article
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Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
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Academic Article
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Harnessing RKIP to Combat Heart Disease and Cancer.
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Academic Article
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Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.
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Academic Article
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SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells.
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Academic Article
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SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
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Concept
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Imatinib Mesylate
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Concept
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X-Box Binding Protein 1
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Concept
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NF-KappaB Inhibitor alpha
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Concept
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A549 Cells
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Concept
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Src Homology 2 Domain-Containing, Transforming Protein 1
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Concept
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F-Box-WD Repeat-Containing Protein 7
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Concept
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Regulatory-Associated Protein of mTOR
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Concept
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Rapamycin-Insensitive Companion of mTOR Protein
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Concept
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MCF-7 Cells
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Concept
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Nestin
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Academic Article
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Nonmonotone invasion landscape by noise-aware control of metastasis activator levels.
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